Endocrine Abstracts

Introduction: Recently, vitamin D3 (cholecalciferol) deficiency has been considered as one of the factors for the development of type 2 diabetes mellitus (T2D) and metabolic syndrome (MS), which contributes to increased insulin resistance (IR) and reduced insulin secretion. The most pronounced vitamin D deficiency is observed in persons suffering from morbid obesity. The aim of this study was to assess IR, b-cell functional activity and metabolic profile parameters according t...

Background and aims: Comparative animal study of efficacy of intermittent short courses administration of lyophilized single-, three- and alive multistrain probiotic on insulin resistance in rats with experimental obesity.Methods: We included 70 rats divided into 7 groups (n=10 in each). Rats of group I were intact. Newborn rats of groups II-VII were injected with monosodium glutamate (MSG) (4 mg/g). Rats of group II (MSG-obesity group) were unt...

Background: Probiotics have beneficial effect on obesity, insulin resistance and associated metabolic disorders. However, effect of probiotics on β-cell function are inconsistent.Aim: In a double-blind single center randomized placebo-controlled trials (RCT), effect of alive multistrain probiotic vs. placebo on β-cell function in type 2 diabetes patient were assessed.Methods: A total of 54 patients met the criteria for in...

Background: Probiotics have beneficial effect on obesity related disorders in animal models. Despite a large number of animal data, randomized placebo-controlled trials (RCT) concluded that probiotics have a moderate effect on glycemic control-related parameters. However, effect of probiotics on insulin resistance are inconsistent.Aim: In a double-blind single center RCT, effect of alive multistrain probiotic vs placebo on insulin resistance in type 2 di...

Introduction: The beneficial interaction between the microbiota and humans is the way how bacteria contained within the gut ‘talk’ to the immune system. Into this landscape probiotics and nutraceuticals play a major role. The study aims to determine whether probiotics plus nutraceuticals such as smectite or omega-3 are superior to probiotic alone on the monosodium glutamate (MSG) induced obesity model in rats.Methods: Totally 7...

Background: Leading position among endocrine pathology of adolescence and young women is type 1 diabetes (T1D), which in recent years had been proved to have a strong association with reproductive dysfunction among such patients. The purpose was to investigate the features of reproductive health in 120 young women (18–22 years old) with T1D.Methods: Retrospectively we studied the features of puberty and prospectively examined level of blood glucose ...

Background: Recently, vitamin D3 deficiency is considered one of the factors associated with the development of non-alcoholic fatty liver disease (NAFLD). The aim was to evaluate steatosis indices and metabolic parameters in NAFLD depending on D3 status.Materials and methods: According to the recommendations of the European Society of Endocrinology, all patients were divided into 3 groups: group 1 – with an optimal level of vitamin D3 (30 ng/m...

Background: One of the most significant complications of type 2 diabetes (T2D) is non-alcoholic fatty liver disease (NAFLD). The search for new effective approaches to the treatment of patients with comorbid chronic condition such as type 2 diabetes and NAFLD is relevant.Methods: We have observed 118 patients, including 64 patients with T2D and NAFLD, 26 patients with T2D and 28 patients with NAFLD. The control group consisted of 25 healthy indivi...

Background: Probiotics and omega-3 polyunsaturated fatty acids supplementation (PUFA) have beneficial effect on obesity related disorders in animal models. We have previously shown, on rats with monosodium glutamate-induced obesity, that in take of the combination based on live probiotics and omega-3 PUFA is accompanied by the preventive effect concerning experimental obesity development, lead toinsulin resistance (IR) improvement and more obvious decrease of he paticsteatosis...